This letter appears tailored to the position, but is 90% generic. You can answer online postings or want ads this way. It's less effective, but still worth doing if you're in a rush.
DAVID L. LOVETT
3851 Westwick Way | Kennesaw, Ga. 30152
O: 678-591-4221 | H: 770-428-2489 | firstname.lastname@example.org
October, 16, 20—
Director of Human Resources
Requisition ID 453
Amersham Biosciences Corporation
Piscataway, NJ 07010
Dear Hiring Manager:
This letter is in response to your advertisement in Monster.com on October 15, 20—. Your ad outlined requirements for the Manager of Health Safety and Environment. This position is very appealing to me since your needs match a great deal of my background. Specifically:
Radiation Safety Manager; Fort Calhoun Station, Radiation Safety Manager; Rocky Flats, Radiation Safety Manager ATG Catalytics, Industrial Safety Assessor, Institute of Nuclear Power Operations.
In the various positions, I was responsible for the development and implementation of various programs, working with regulators on a daily basis, advising management and making reports for those reportable conditions that may occur.
In closing, I would look forward to receiving consideration for your position and hope to hear from you soon. If you would like additional information on my background and accomplishments, please don’t hesitate to call me.
With sincere regards,
David L. Lovett